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The only plausible theory the author is able to venture regarding their embryonic evolution is the faulty closure of that part of the genital cleft concerned in the formation of the urethral tract synchronous with faulty or delayed participation in the development of the epibiast lining it.

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In the author's opinion it is extremely doubtful if the plague bacillus can be held responsible for the full development of the bubo; in fact, his own experience leads me to believe that buboes are the result of the local growth of the Bacillus t'cstis plus pyogenic bacteria, and the latter by their more active growth cause a full development of the bubo with all its typical pathological appearances, and eventually crowd out the actual bacillus pestis itself. From approximately study were required for graduation.

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