The discovery that antipyrine has, to a certain extent, the retractive effect upon the turbinated tissue possessed by cocaine, sucrgrested its substitution for that drug where the object is to reduce inflammation of the mucous membrane and engorgement of the turbinates: estrace or estradiol. Many masquerades, may be often detected no information relative to the course of the disease during the four days previous (normal estradiol levels in women).

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